Pharmacological basis of asthma and allergy: A collection of seminal articles

Pharmacological basis of asthma and allergy: A collection of seminal articles

The allergology just began over 100 years ago around a new knowledge, a new name and new therapeutic interventions that required a high degree of specialization. The new knowledge was organized around the recently discovered immune system and the group of strange diseases it caused in response to harmless agents. The new name was taken from the neologism ‘allergy’ coined in 1906 by the Viennese paediatrician Clemens von Pirquet, in fact a poorly understood but appealing word. The new therapeutic interventions were mainly non-pharmacological, aimed to reinforce or change the natural immunity. Not many drugs were included in them, in part because a new understanding of the therapeutics and because a shortage of really effective drugs in that time.

In view of this background, it could seem difficult to write an issue of Pharmacotherapy Revisited dedicated to allergology. But the next decades of the twentieth century witnessed the development of powerful new drugs that eventually became as important as immunological techniques in the therapeutic armamentarium of allergists. Nowadays, both types of interventions complement one another in the treatment of the complex and prevalent diseases of the immune system studied by allergists.

In this book, the major allergological therapeutic interventions, pharmacological and non-pharmacological, will be presented along with its historical development. Furthermore, we will highlight the authors and seminal papers that contributed to the modern therapeutic in allergology and in this way we will know better the main advances occurred in the history of this young medical discipline. This will be the best way to understand the exciting new therapeutic discoveries about to arrive.

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Full document Juan Manuel Igea
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Introduction Juan Manuel Igea
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1. Weiterer Beitrag zur Ursache und spezifischen Heilung des Heufiebers WP. Dunbar
2. Etiology and specific therapy of hay fever WP. Dunbar
3. The present state of our kwowledge of hay-fever WP. Dunbar
4. Prophylactic inoculation against hay fever L. Noon
5. Further observation on the treatment of hay fever by hypodermic inoculation of pollen vaccine J. Freeman / L. Noon
6. Prophylaxis of summer hay-fever and asthma. A controlled trial comparing crude grass-pollen extracts with the isolated main protein component AW. Frankland / R. Augustin
7. A double-blind study of the effectiveness and specificity of injection therapy in ragweed hay fever FC. Lowell / W. Franklin
8. Clinical and in vitro studies on the role of immunotherapy in ragweed hay fever LM. Lichtenstein / PS. Norman / WL. Winkenwerder
9. Low dose sublingual therapy in patients with allergic rhinitis due to house dust mite GK. Scadding / J. Brostoff
10. Proceedings of the Physiological Society, March 10, 1984. No. I. On the physiological action of the suprarenal capsules G. Oliver G / EA. Schäfer
11. The physiological effects of extracts of the suprarenal capsules G. Oliver / EA. Schäfer
12. Adrenalin the active principle of the suprarenal glands and its mode of preparation J. Takamine
13. Clinical observations on the pathophysiology and treatment of anaphylactic cardiovascular collapse MM. Fisher
14. On the hyperdermatic use of adrenalin chloride in the treatment of asthmatic attacks JGM. Bullowa / DM. Kaplan
15. A study of the adrenotropic receptors RP. Ahlquist
16. Differentiation of receptor systems activated by sympathomimetic amines AM. Lands / A. Arnold / JP. McAuliff / FP. Luduena / TG. Brown
17. The physiological action of β-iminazolylethylamine HH. Dale / PP. Laidlaw
18. Histamine shock HH. Dale / PP. Laidlaw
19. Action protectrice des éthers phénoliques au cours de l’intoxication histaminique D. Bovet / AM. Staub
20. The use of adrenal substance in the treatment of asthma S. Solis-Cohen
21. Analgesia accompanying hepatitis and jaundice in cases of chronic arthritis, fibrositis and sciatic pain PS. Hench
22. The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone: compound E) and the pituitary adrenocorticotrophic hormone on rheumatoid arthritis. Preliminary report PS. Hench / EC. Kendall / CH. Slocumb / HF. Polley
23. Controlled trial of effects of cortisone acetate in status asthmaticus. Report to the Medical Research Council by the Subcommittee on Clinical Trials in Asthma Medical Research Council
24. Beclomethasone dipropionate: a new steroid aerosol for the treatment of allergic asthma H. Morrow Brown / G. Storrey / WHS. George
25. Therapeutic uses of khellin. Method of standardisation GV. Anrep GV / MR. Kenawy / GS. Barsoum / G. Misrahy
26. A double-blind trial of disodium cromoglycate in the treatment of allergic bronchial asthma JBL. Howell / REC. Altounyan
27. Passive cutaneous anaphylaxis in the rat, induced with two homologous reagin-like antibodies and its specific inhibition with disodium cromoglycate J. Goose / AMJN. Blair
28. The liberation of a slow-reacting smooth muscle-stimulating substance in anaphylaxis CE. Kellaway / ER. Trethewie
29. Leukotriene C: a slow-reacting substance from murine mastocytoma cells RC. Murphy / S. Hammarström / B. Samuelsson
30. Monoclonal antibodies specific for human IgE-producing B cells: a potential therapeutic for IgE-mediated allergic diseases TW. Chang TW / FM. Davis FM / NC. Sun NC / CRY. Sun / DW. MacGlashan /
RG. Hamilton
31. The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: efficacy, safety, and pharmacokinetics J. Corne / R. Djukanovic / L. Thomas / J. Warner / L. Botta / B. Grandordy et al.
32. Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE M. Humbert / R. Beasley / J. Ayres / R. Slavin / J. Hebert /
J. Bousquet et al.