Drug transport(ers) and the diseased brain | Fundació Dr. Antonio Esteve

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2005

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La barrera hemato-encefàlica (BHE) és un dispositiu selectiu que actua de filtre entre la sang circulant i els teixits cerebrals i que impedeix la penetració al cervell de substàncies nocives. Però, el que per una banda resulta beneficiós, ja que evita l’entrada de substàncies perjudicials, es converteix en un obstacle per a l’eficàcia de determinats fàrmacs que exerceixen el seu efecte terapèutic en el cervell.

La BHE va ser el fil conductor de l’onzè simposi internacional organitzat per la Fundació Dr. Antoni Esteve l’octubre de 2004. Al llarg de tres jornades, 19 investigadors de tot el món van presentar els seus treballs sobre aquest dispositiu amb l’objectiu de conèixer més coses sobre ell: les possibles alteracions d’aquesta barrera en condicions patològiques, les modalitats de transport i les noves possibilitats de desenvolupament de nous fàrmacs i nous sistemes de transport amb la finalitat d’afavorir el pas de principis actius a través de la BHE. No és un tema menor si tenim en compte que d’això depèn en bona mesura el desenvolupament de medicaments per al tractament de malalties tan importants com l’Alzheimer, el Parkinson o l’Esclerosi Múltiple.

Albert de Boer, del departament de Farmacologia del Leiden-Amsterdam Center for Drug Research va ser l’encarregat de moderar aquesta reunió científica i d’editar aquest volum número 11 de la sèrie Esteve Foundation Symposia, publicada per Elsevier.

Capítols
Introduction	Albertus G. de Boer	[wpdm id=311 type=”btn”]
List of participants		[wpdm id=312 type=”btn”]
1. Physiology of the blood-brain barrier and its consequences for drug transport to the brain	N. Joan Abbott	[wpdm id=289 type=”btn”]
2. The blood-brain barrier and treatment of lysosomal storage diseases	J.M. Aerts / M.J. van Breemen / A.R. Bussink / J. Brinkman / C.E.M. Hollak / M. Langeveld / G.E. Linthors / A.C. Vedder / M. de Post	[wpdm id=290 type=”btn”]
3. The priorities/needs of the pharmaceutical industry in drug delivery to the brain	Michel Lemaire / Sandrine Desrayaud	[wpdm id=291 type=”btn”]
4. Drug and gene targeting to the brain via blood-brain barrier receptor-mediated transport systems	William M. Pardridge	[wpdm id=292 type=”btn”]
5. Carrier-mediated transport to enhance drug delivery to brain	Quentin R. Smith	[wpdm id=293 type=”btn”]
6. Influx transporters and drug targeting: Application of peptide and cation transporters	Akira Tsuji	[wpdm id=294 type=”btn”]
7. Application of nanoparticles for the delivery of drugs to the brain	Jorg Kreuter	[wpdm id=295 type=”btn”]
8. Application, efficiency and cargo-dependence of transport peptides	J.P.M. Langedijk / T. Olijhoek / R.H. Meloen	[wpdm id=296 type=”btn”]
9. Efflux transport systems at the blood-brain barrier and blood CSF barrier	Hiroyuki Kusuhara / Yuichi Sugiyama	[wpdm id=297 type=”btn”]
10. Experimental models to evaluate the role of P-glycoprotein in the blood-brain tumor barrier	Olaf van Tellingen / E. Marleen Kemper / Tessa Buckle	[wpdm id=298 type=”btn”]
11. Overcoming MDR at the blood-brain barrier	G. Fricker	[wpdm id=299 type=”btn”]
12. Reversal of MDRl/P-glycoprotein-mediated multidrug resistance by RNA interference	H. Lage	[wpdm id=300 type=”btn”]
13. The multidrug resistance protein BMDP/ABCG2: A new and highly relevant efflux pump at the blood-brain barrier	A. Drees / E. Hollnack / T. Eisenblatter / H.J. Galla	[wpdm id=301 type=”btn”]
14. Development of a potential protein vector (NeuroTrans) to deliver drugs across the blood-brain barrier	R. Gabathuler / G. Arthur / M. Kennard / Q. Chen / S. Tsai / J. Yang / W. Schoorl / T.Z. Vitalis / W.A. Jefferies	[wpdm id=302 type=”btn”]
15. Diphtheria toxin receptor-targeted brain drug delivery	P.J. Gaillard / A. Brink / A.G. de Boer	[wpdm id=303 type=”btn”]
16. The use of Pep: Trans vectors for the delivery of drugs into the central nervous system	J.M. Scherrmann / J. Temsamani	[wpdm id=304 type=”btn”]
17. Single domain antibodies as blood-brain barrier delivery vectors	A. Abulrob / J. Zhang / J. Tanha / R. MacKenzie / D. Stanimirovic	[wpdm id=305 type=”btn”]
18. The blood-brain barrier in trauma, stroke and edema	J. Verlooy / J. Van Reempts	[wpdm id=306 type=”btn”]
19. The blood-brain barrier in multiple sclerosis	S. McQuaid / J. Kirk	[wpdm id=307 type=”btn”]
20. The blood-brain barrier in diabetes mellitus: A critical review of clinical and experimental findings	E. Tolia / I.P. Fouyas / P.A.T. Kelly / I.R. Whittle	[wpdm id=308 type=”btn”]
Final discussion	A.G. de Boer	[wpdm id=310 type=”btn”]
Novel opportunities for the treatment of brain diseases	A.G. de Boer	[wpdm id=309 type=”btn”]

2. The blood-brain barrier and treatment of lysosomal storage diseases
J.M. Aerts / M.J. van Breemen / A.R. Bussink / J. Brinkman / C.E.M. Hollak / M. Langeveld / G.E. Linthors / A.C. Vedder / M. de Post
Descarregar

10. Experimental models to evaluate the role of P-glycoprotein in the blood-brain tumor barrier
Olaf van Tellingen / E. Marleen Kemper / Tessa Buckle
Descarregar

18. The blood-brain barrier in trauma, stroke and edema
J. Verlooy / J. Van Reempts
Descarregar

3. The priorities/needs of the pharmaceutical industry in drug delivery to the brain
Michel Lemaire / Sandrine Desrayaud
Descarregar

11. Overcoming MDR at the blood-brain barrier
G. Fricker
Descarregar

19. The blood-brain barrier in multiple sclerosis
S. McQuaid / J. Kirk
Descarregar

4. Drug and gene targeting to the brain via blood-brain barrier receptor-mediated transport systems
William M. Pardridge
Descarregar

12. Reversal of MDRl/P-glycoprotein-mediated multidrug resistance by RNA interference
H. Lage
Descarregar

20. The blood-brain barrier in diabetes mellitus: A critical review of clinical and experimental findings
E. Tolia / I.P. Fouyas / P.A.T. Kelly / I.R. Whittle
Descarregar

5. Carrier-mediated transport to enhance drug delivery to brain
Quentin R. Smith
Descarregar

13. The multidrug resistance protein BMDP/ABCG2: A new and highly relevant efflux pump at the blood-brain barrier
A. Drees / E. Hollnack / T. Eisenblatter / H.J. Galla
Descarregar

Final discussion
A.G. de Boer
Descarregar

6. Influx transporters and drug targeting: Application of peptide and cation transporters
Akira Tsuji
Descarregar

14. Development of a potential protein vector (NeuroTrans) to deliver drugs across the blood-brain barrier
R. Gabathuler / G. Arthur / M. Kennard / Q. Chen / S. Tsai / J. Yang / W. Schoorl / T.Z. Vitalis / W.A. Jefferies
Descarregar

Novel opportunities for the treatment of brain diseases
A.G. de Boer
Descarregar

Drug transport(ers) and the diseased brain Introduction
Albertus G. de Boer
Descarregar

7. Application of nanoparticles for the delivery of drugs to the brain
Jorg Kreuter
Descarregar

15. Diphtheria toxin receptor-targeted brain drug delivery
P.J. Gaillard / A. Brink / A.G. de Boer
Descarregar

Drug transport(ers) and the diseased brain List of participants
Descarregar

8. Application, efficiency and cargo-dependence of transport peptides
J.P.M. Langedijk / T. Olijhoek / R.H. Meloen
Descarregar

16. The use of Pep: Trans vectors for the delivery of drugs into the central nervous system
J.M. Scherrmann / J. Temsamani
Descarregar

1. Physiology of the blood-brain barrier and its consequences for drug transport to the brain
N. Joan Abbott
Descarregar

9. Efflux transport systems at the blood-brain barrier and blood CSF barrier
Hiroyuki Kusuhara / Yuichi Sugiyama
Descarregar

17. Single domain antibodies as blood-brain barrier delivery vectors
A. Abulrob / J. Zhang / J. Tanha / R. MacKenzie / D. Stanimirovic
Descarregar