11th Award: A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition

Santiago Ropero and Manel Esteller worked together in the epigenetics laboratory of the National Cancer Research Center (Centro Nacional de Investigaciones Oncológicas) (CNIO) when they published in Nature Genetics in 2006 the discovery of the mutation in an epigenetic gene in human cancer. Three years later, Ropero, from the department of biochemistry and molecular biology at the University…