11th Award: A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition

Santiago Ropero and Manel Esteller worked together in the epigenetics laboratory of the National Cancer Research Center (Centro Nacional de Investigaciones Oncológicas) (CNIO) when they published in Nature Genetics in 2006 the discovery of the mutation in an epigenetic gene in human cancer. Three years later, Ropero, from the department of biochemistry and molecular biology at the University…

Migraine headache: Current knowledge and future therapies

Migraine continues to remain a major scientific mystery. We know that it is preceded by premonitory symptoms such as aura or impaired vision in some cases, causing nausea and unilateral pain accompanied by intense headache, and involves sensory distress such as photophobia or excessive sensitivity to sound. However, the treatment of migraine remains a major… 2009