The Research Award recognises once every two years a spanish author who has published what is considered by the international jury to be the best article related to pharmacotherapy in any scientific journal in the world.

Double Foundation Esteve Research Award for the treatment of two rare diseases

For the second time in history, the Foundation Esteve Research Award has finally been granted to two works. The international jury grants this award every two years, and considered these works to be the two best pharmacology research articles published by Spanish authors. The award, which has a prize of 18,000 euros, will be shared…

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13th Award: Effect of Multikinase Inhibitors on Caspase-Independent Cell Death and DNA Damage in HER2-Overexpressing Breast Cancer Cells

A combination of two drugs, trastuzumab and dasatinib, improve the treatment response by 30% in breast cancers, those in which tumour cells show an overexposure to the HER2 protein. This is the discovery of four scientists from Cancer Research Centre (CIC-IBMCC), part of the University of Salamanca and CSIC, who were awarded the 13th Esteve…

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12th Award: Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling

The 12th Esteve Foundation Research Prize has been awarded to Emma Puighermanal, the first author on an article from the research group ofRafael Maldonado (Neuropharmacology Laboratory, Pompeu Fabra University) published in Nature Neuroscience in September 2009.The title of the paper was Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling and it was considered by the international jury that…

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11th Award: A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition

Santiago Ropero and Manel Esteller worked together in the epigenetics laboratory of the National Cancer Research Center (Centro Nacional de Investigaciones Oncológicas) (CNIO) when they published in Nature Genetics in 2006 the discovery of the mutation in an epigenetic gene in human cancer. Three years later, Ropero, from the department of biochemistry and molecular biology at the University…

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10th Award: Application of Stereocontrolled Stepwise [3+2] Cycloadditions to the Preparation of Inhibitors of alpha(4) beta(1)-Integrin-Mediated Hepatic Melanoma Metastasis

Aizpea Zubia and Fernando Cossío are the visible heads of the team from the Faculty of Chemistry of the University of the Basque Country that was awarded the 10th Research Prize granted by the Esteve Foundation. Among 45 nominated articles, the development of a family of synthetic molecules able to restrain liver metastases by 50% in experimental melanoma…

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9th Award: Attenuation of thermal nociception and hyperalgesia by VR1 blockers

The discovery of two new compounds likely to be developed as analgesics for inflammatory pain management is the study awarded with the ninth Research Prize of the Esteve Foundation. This work, published in February 2002 in the American journal Proceedings of the National Academy of Sciences, was performed jointly by investigators of the CSIC and of…

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8th Award: An anorexic lipid mediator regulated by feeding

This prize, offered biennially by the Esteve Foundation to the best work on pharmacological research, was awarded this year to Fernando Rodríguez de Fonseca, current Research Director of the Hospital and Foundation Carlos Haya, for the study An anorexic lipid mediator regulated by feeding, published in Nature (2001; 414:209-12). In this work, the main contribution was the discovery…

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