The arrival of computer-based databases and their influence in clinical research is the starting point of this round table held on November 23, 1995 at the Princesa Sofía hotel of Barcelona. Moderated by José Elguero, from the Medical Chemistry Institute of the CSIC (High Council for Scientific Research), and by Susana Pérez Gutthann, from the Medical Department of Ciba Geigy, SA, the round table Pharmacology and therapeutics databases discussed topics like computer-assisted molecular design, bibliographic search techniques, application of computer-based methods in clinical trials, or computerization of therapeutic prescriptions. A total of 10 submissions are reproduced in Dr. Antonio Esteve’s Monograph number 18.