Xavier Carné, from the Service of Clinical Pharmacology of the Clinic Hospital of Barcelona, and Joan Costa, from the same department at the Germans Trias i Pujol Hospital of Badalona, moderated the round table titled Problems and controversies regarding clinical trials. This round table was held on October 16, 1997 at the Princesa Sofía Hotel of Barcelona, and topics like the informed consent and its limitations, the legitimacy of the use of placebos or the diffusion of results of clinical trials in the daily press, were discussed. A total of eleven submissions are compiled in Dr. Antonio Esteve’s Monograph number 22.