The first international symposium organized by the Esteve Foundation, held on October 15-17, 1984, was born with the purpose of reuniting several experts on drug-protein binding in order to discuss the biological bases and the biochemical mechanisms of binding, as well as their involvement in a number of diseases. Indeed, the different degree of binding of drugs to plasma proteins may have important clinical repercussions on specific diseases or physiological states of the human being. Marcus Reidenberg (Cornell University Medical College, New York) and Sergio Erill (Esteve Foundation) gathered each submission and their respective discussions in the first volume of the Esteve Foundation Symposia series, published by Praeger Scientific