Dr. Antoni Esteve Foundation Research Award 2021

In 2019, a group from the Centro Nacional de Investigaciones Cardiovasculares published in the journal Nature relevant data around the involvement of the p38gamma protein in the development of the main type of primary liver cancer. This is hepatocellular carcinoma, which affects more than one million people a year worldwide and for which few pharmacological…

2021

13th Award: Effect of Multikinase Inhibitors on Caspase-Independent Cell Death and DNA Damage in HER2-Overexpressing Breast Cancer Cells

A combination of two drugs, trastuzumab and dasatinib, improve the treatment response by 30% in breast cancers, those in which tumour cells show an overexposure to the HER2 protein. This is the discovery of four scientists from Cancer Research Centre (CIC-IBMCC), part of the University of Salamanca and CSIC, who were awarded the 13th Esteve…

2013

12th Award: Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling

The 12th Esteve Foundation Research Prize has been awarded to Emma Puighermanal, the first author on an article from the research group ofRafael Maldonado (Neuropharmacology Laboratory, Pompeu Fabra University) published in Nature Neuroscience in September 2009.The title of the paper was Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling and it was considered by the international jury that…

2011

11th Award: A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition

Santiago Ropero and Manel Esteller worked together in the epigenetics laboratory of the National Cancer Research Center (Centro Nacional de Investigaciones Oncológicas) (CNIO) when they published in Nature Genetics in 2006 the discovery of the mutation in an epigenetic gene in human cancer. Three years later, Ropero, from the department of biochemistry and molecular biology at the University…

2009

10th Award: Application of Stereocontrolled Stepwise [3+2] Cycloadditions to the Preparation of Inhibitors of alpha(4) beta(1)-Integrin-Mediated Hepatic Melanoma Metastasis

Aizpea Zubia and Fernando Cossío are the visible heads of the team from the Faculty of Chemistry of the University of the Basque Country that was awarded the 10th Research Prize granted by the Esteve Foundation. Among 45 nominated articles, the development of a family of synthetic molecules able to restrain liver metastases by 50% in experimental melanoma…

2007

8th Award: An anorexic lipid mediator regulated by feeding

This prize, offered biennially by the Esteve Foundation to the best work on pharmacological research, was awarded this year to Fernando Rodríguez de Fonseca, current Research Director of the Hospital and Foundation Carlos Haya, for the study An anorexic lipid mediator regulated by feeding, published in Nature (2001; 414:209-12). In this work, the main contribution was the discovery…

2003