Molecular biology and pharmacology of tissue repair

Diseases associated with impaired tissue repair are common clinical problems. Therefore, the elucidation of the molecular basis of normal and impaired repair will help to define new therapeutic targets to alleviate and eventually cure these illnesses. Furthermore, recent studies have revealed remarkable similarities between tissue repair and cancer at the cellular and molecular level. Thus,… 2007

Drug transport(ers) and the diseased brain

The blood-brain barrier (BBB) is a selective device that acts as a filter between circulating blood and brain tissues, in order to prevent the penetration of harmful substances into the brain. However, this benefit of preventing the entry of harmful substances becomes an obstacle to the efficacy of certain drugs that exert their therapeutic effect… 2005

Inverse agonism

This tenth volume of the Esteve Foundation gathers existing data, new findings and future perspectives related to reverse agonism. Its contents is the result of the symposium held in S’Agaró (Girona) in 2002, moderated by Adriaan Ijzerman, from the Leiden/Amsterdam Center for Drug Research. Twenty-three submissions were presented, one of them by the only Spanish representative,… 2003

Optimal dose identification

This publication is the result of the international symposium on dose identification organized by the Esteve Foundation in Lloret de Mar (Girona) on October 4-7, 2000. The book collects the submissions of the participating scientists and is edited by Alasdair Breckenridge, from the Department of Pharmacology and Therapeutics of the University of Liverpool. The objective of… 2001

Variability in human drug response

The fact that each patient reacts differently to one given treatment is both an obstacle and a challenge for pharmacology. The eighth international symposium organized by the Esteve Foundation included several aspects related to the diversity of responses to drugs. Geoffrey T. Tucker, from the Department of Molecular Pharmacology and Pharmacogenetics of the University of… 1999

The clinical pharmacology of sport and exercise

As antidoping controls have gained wide repercussion in the media on account of their performance in great contests, much talk has ensued regarding the misuse of drugs in sports. However, there is little discussion about the true effect of medicinal products on physical performance or about whether evidence of all possible drug-related effects on exercise… 1997

The pharmacology of sexual function and dysfunction

How can pharmacology contribute to clinically improve a number of existing sexual problems? Also, what are the repercussions on the sexual function secondary to the use of drugs for the treatment of other diseases? Professional researchers in the field of sexual pharmacology gathered in an international symposium organized by the Esteve Foundation to contribute their… 1995

The pharmacology of cell differentiation

This number 5 of the Esteve Foundation Symposia series is the result of the international symposium organized by the Esteve Foundation in October 1992 on the pharmacology of cell differentiation, and is edited by R.A. Rifkind, from the Sloan-Kettering Institute of New York. In this meeting, the general and specific mechanisms involved in the inter- and intra-cellular… 1993

The clinical pharmacology of biotechnology products

Marcus M. Reidenberg, from the Department of Pharmacology and Medicine of the Faculty of Medicine of Cornell University (New York), edited this volume number 4 of the Esteve Foundation Symposia series. The new molecular and cell biology techniques provide different opportunities to develop new agents for the diagnosis, treatment and prevention of diseases. Clinical pharmacologists,… 1991

Dose-response relationships in clinical pharmacology

The third international symposium organized by the Esteve Foundation resulted in this new publication of the Esteve Foundation Symposia series, focusing on the dose-response relationship in clinical pharmacology. Professors Lasagna, Erill and Naranjo edited the book gathering the different submissions and their respective discussions. Finding a clear relationship between the dose or concentration of a… 1989