Metodología del ensayo clínico

Clinical trials are experimental studies performed in patients or healthy volunteers to assess the efficacy and safety of drugs or other therapeutical procedures. It differs from clinical observation in data collection and in the need for comparison of results with another reference or control group. As from 1982, the authorization by the Spanish General Direction…

1991

The clinical pharmacology of biotechnology products

Marcus M. Reidenberg, from the Department of Pharmacology and Medicine of the Faculty of Medicine of Cornell University (New York), edited this volume number 4 of the Esteve Foundation Symposia series. The new molecular and cell biology techniques provide different opportunities to develop new agents for the diagnosis, treatment and prevention of diseases. Clinical pharmacologists,…

1991

Biotecnología de aplicación farmacéutica

The advances in biotechnology are due to the better knowledge of the nature of live organisms and to the technological capacity developed to alter their genetic information. The aim of the round table organized by the Esteve Foundation in 1989 and of this publication was to analyze the scientific development of biotechnology in the pharmaceutical…

1991

Perspectivas terapéuticas en la esclerosis múltiple

One of the diseases affecting the central nervous system that most interests the scientific community is multiple sclerosis. Although it was described by Charcot more than a century ago, many aspects of this disease remain unsolved. It is still a condition of unknown etiology and difficult diagnosis, whose evolution is often unpredictable and which lacks…

1989

Tratamiento de datos en farmacología

In this Dr. Antonio Esteve’s Monograph, some of the aspects related to the quantitative analysis of results in pharmacology, as submitted by different Spanish scientists in a round table held in Barcelona in May 1988, are reviewed and updated. Topics like the analysis of the response to agonistic drugs, receptor binding and discrimination studies or…

1989

Dose-response relationships in clinical pharmacology

The third international symposium organized by the Esteve Foundation resulted in this new publication of the Esteve Foundation Symposia series, focusing on the dose-response relationship in clinical pharmacology. Professors Lasagna, Erill and Naranjo edited the book gathering the different submissions and their respective discussions. Finding a clear relationship between the dose or concentration of a…

1989

Investigación básica y medicina clínica

The objective of this monograph, which gathers the submissions and discussions of a round table held in Barcelona in 1987, was to introduce recently graduated doctors to the links between basic research and clinical practice. For that purpose, a series of researchers that combined both tasks disclosed the investigational work done. The objective was no…

1988