Author
Diseases associated with impaired tissue repair are common clinical problems. Therefore, the elucidation of the molecular basis of normal and impaired repair will help to define new therapeutic targets to alleviate and eventually cure these illnesses. Furthermore, recent studies have revealed remarkable similarities between tissue repair and cancer at the cellular and molecular level. Thus, the characterization of the mechanisms underlying normal repair processes will also enhance our knowledge on the pathogenesis of cancer and provide the basis for the development of novel cancer therapeutics. In recent years, our understanding on the molecular and cellular mechanisms involved in tissue repair has strongly increased, and some of the regulatory genes and signalling cascades have been identified. Furthermore, new strategies have been developed for the improvement of organ regeneration involving the use of growth factors of matrix proteins, stem cells and new biomaterials.
This Esteve Foundation Symposia number 12 summarizes the work of major experts in the tissue repair field. Similarities and differences in repair of different tissues and organs are reviewed, and the parallels between tissue repair and embryonic development, as well as between tissue repair and cancer are reported. Therefore, this volume will be of interest for basic scientists who work on embryonic development, tissue repair and cancer as well as for clinicians of different disciplines.
Esteve Foundation Symposia are published by Elsevier and on sale in scientific bookshops worldwide. While the Foundation obtains no profit on sales, a small number of copies is provided by the publishing house and distributed to the participants, to certain libraries and to scientists with a special interest on the topic.
| Full document | ||
| Full PDF | S. Werner | [wpdm type=”btn3″] |
| Chapters | ||
| 1. Wound healing and inflammation studies in genetically tractable organisms | P. Martin | [wpdm type=”btn3″] |
| 2. Endothelial cell contacts in inflammation and angiogenesis | D. Vestweber | [wpdm type=”btn3″] |
| 3. Antimicrobial peptides: Effector molecules of the cutaneous defense system | J.M. Schröder / R. Gläser / J. Harder | [wpdm type=”btn3″] |
| 4. Functional properties of CYLD | R. Massoumi / R. Fässler | [wpdm type=”btn3″] |
| 5. Roles of the peroxisome proliferator-activated receptor (PPAR) ? and ?/? in skin wound healing | L. Michalik / W. Wahli | [wpdm type=”btn3″] |
| 6. Novel actions of cardiac ankyrin repeat protein | S.E. Samaras / Y. Shi / J.M. Davidson | [wpdm type=”btn3″] |
| 7. The FGF ligand-receptor signaling system in chondrogenesis, osteogenesis and vascularization of the endochondral skeleton | K. Yu / D.M. Ornitz | [wpdm type=”btn3″] |
| 8. From adiposity to bone | B. Slater / M. Kwan / D. Wan / M. Longaker | [wpdm type=”btn3″] |
| 9. Cellular and molecular bases of muscle regeneration: the critical role of insulin-like growth factor-1 | A. Musarò / C. Giacinti / L. Pelosi / B.M. Scicchitano / M. Molinaro | [wpdm type=”btn3″] |
| 10. TGF? and Smad3 link inflammation to progressive fibrosis | J. Gauldie / P. Bonniaud / P. Margetts / P. Sime / K. Ask / M. Kolb | [wpdm type=”btn3″] |
| 11. Role of metalloproteinases in epithelial repair | W.C. Parks | [wpdm type=”btn3″] |
| 12. Rebuilding the liver with adult hepatic and embryonic stem cells | J. Heo / V.M. Factor / S.S. Thorgeirsson | [wpdm type=”btn3″] |
| 13. Repair of injured fiber tracts in the mammalian central nervous system | M.E. Schwab | [wpdm type=”btn3″] |
| 14. The Nrf2-ARE pathway: a potential therapeutic target for neurodegenerative diseases | J.A. Johnson / D.A. Johnson / J.M. Lee / J. Li / A.D. Kraft / M.J. Calkins / R.J. Jakel | [wpdm type=”btn3″] |
| 15. Central nervous system repair and stem cells | R. Jandial / I. Singec / V.J. Duenas / A.L. Ho / M.L. Levy / E.Y. Snyder | [wpdm type=”btn3″] |
- 4. Functional properties of CYLD
- R. Massoumi / R. Fässler
- Download
- 12. Rebuilding the liver with adult hepatic and embryonic stem cells
- J. Heo / V.M. Factor / S.S. Thorgeirsson
- Download
- 5. Roles of the peroxisome proliferator-activated receptor (PPAR) ? and ?/? in skin wound healing
- L. Michalik / W. Wahli
- Download
- 13. Repair of injured fiber tracts in the mammalian central nervous system
- M.E. Schwab
- Download
- 6. Novel actions of cardiac ankyrin repeat protein
- S.E. Samaras / Y. Shi / J.M. Davidson
- Download
- 14. The Nrf2-ARE pathway: a potential therapeutic target for neurodegenerative diseases
- J.A. Johnson / D.A. Johnson / J.M. Lee / J. Li / A.D. Kraft / M.J. Calkins / R.J. Jakel
- Download
- 7. The FGF ligand-receptor signaling system in chondrogenesis, osteogenesis and vascularization of the endochondral skeleton
- K. Yu / D.M. Ornitz
- Download
- 15. Central nervous system repair and stem cells
- R. Jandial / I. Singec / V.J. Duenas / A.L. Ho / M.L. Levy / E.Y. Snyder
- Download
- 8. From adiposity to bone
- B. Slater / M. Kwan / D. Wan / M. Longaker
- Download
- 1. Wound healing and inflammation studies in genetically tractable organisms
- P. Martin
- Download
- 9. Cellular and molecular bases of muscle regeneration: the critical role of insulin-like growth factor-1
- A. Musarò / C. Giacinti / L. Pelosi / B.M. Scicchitano / M. Molinaro
- Download
- 2. Endothelial cell contacts in inflammation and angiogenesis
- D. Vestweber
- Download
- 10. TGF? and Smad3 link inflammation to progressive fibrosis
- J. Gauldie / P. Bonniaud / P. Margetts / P. Sime / K. Ask / M. Kolb
- Download
- 3. Antimicrobial peptides: Effector molecules of the cutaneous defense system
- J.M. Schröder / R. Gläser / J. Harder
- Download
- 11. Role of metalloproteinases in epithelial repair
- W.C. Parks
- Download
