Author
The fact that each patient reacts differently to one given treatment is both an obstacle and a challenge for pharmacology. The eighth international symposium organized by the Esteve Foundation included several aspects related to the diversity of responses to drugs. Geoffrey T. Tucker, from the Department of Molecular Pharmacology and Pharmacogenetics of the University of Sheffield, edited this volume number 8 of Esteve Foundation Symposia, published by Elsevier Science.
| Chapters | ||
| Introduction | G. Tucker | [wpdm id=240 type=”btn”] |
| List of participants | [wpdm id=241 type=”btn”] | |
| 1. Pharmacokinetic / pharmacodynamic impact of genetic polymorphism of drug metabolizing enzymes | H.K. Kroemer / W. Siegmund | [wpdm id=217 type=”btn”] |
| 2. Clinical Aspects of Polymorphic Drug Metabolism | G.T. Tucker | [wpdm id=218 type=”btn”] |
| 3. Enzyme Inhibition and Induction – PK/PD Impact | U. Klotz / K.T. Kivistö | [wpdm id=219 type=”btn”] |
| 4. Adverse drug reactions: role of enzyme inhibition and induction | M. Pirmohamed / B. Kevin Park | [wpdm id=220 type=”btn”] |
| 5. Approaches to studying the role of transporters in drug interactions in man | P.B. Watkins | [wpdm id=221 type=”btn”] |
| 6. Genetic polymorphisms in cardiovascular disease: focus on renin angiotensin system | G.K. Davis / N.H. Naqvi | [wpdm id=222 type=”btn”] |
| 7. Pharmacogenetics of respiratory system drugs | I.P. Hall | [wpdm id=223 type=”btn”] |
| 8. Tolerance as a Modulator of Drug Response | N.L. Benowitz | [wpdm id=224 type=”btn”] |
| 9. Variability in human drug response. Age as a source of variability | M.T. Kinirons | [wpdm id=225 type=”btn”] |
| 10. Gender as a source of variability in human pharmacokinetics and pharmacodynamics | P. Rolan / L. McKeown | [wpdm id=226 type=”btn”] |
| 11. Ethnic differences in drug response: A model for understanding interindividual variability | A.J.J. Wood | [wpdm id=227 type=”btn”] |
| 12. Effect of disease on the pharmacokinetic and pharmacodynamic determinants of response to diuretics | D. Craig Brater | [wpdm id=228 type=”btn”] |
| 13. Effects of exercise on human drug response | M.A. van Baak | [wpdm id=229 type=”btn”] |
| 14. Benefit risk evaluation of medicinal products – an epidemiological approach | C. Martinez | [wpdm id=230 type=”btn”] |
| 15. Pain – How to standardize a subjective measure | E. Anneli Kalso | [wpdm id=231 type=”btn”] |
| 16. Variable patient compliance as a source of variability in drug response | J. Urquhart | [wpdm id=232 type=”btn”] |
| 17. Placebo Response | M. Lader | [wpdm id=233 type=”btn”] |
| 18. Pharmacogenetic basis of variation in drug dependence | E.M. Sellers / M.K. Romach / R.F. Tyndale | [wpdm id=234 type=”btn”] |
| 19. Role of phenotyping and genotyping in the measurement of variability in human drug response | J. Benítez | [wpdm id=235 type=”btn”] |
| 20. Population Modelling | L. Aarons | [wpdm id=236 type=”btn”] |
| 21. Can we design drugs with low variability | D. Smith | [wpdm id=237 type=”btn”] |
| 22. Management of variability through dosage form design | P. du Souich / A.O.S. El-Kadi / A.M. Bleau | [wpdm id=238 type=”btn”] |
| 23. Management of Variability – Regulatory Aspects | T. Salmonson / J.R. Wade | [wpdm id=239 type=”btn”] |
- 2. Clinical Aspects of Polymorphic Drug Metabolism
- G.T. Tucker
- Download
- 10. Gender as a source of variability in human pharmacokinetics and pharmacodynamics
- P. Rolan / L. McKeown
- Download
- 18. Pharmacogenetic basis of variation in drug dependence
- E.M. Sellers / M.K. Romach / R.F. Tyndale
- Download
- 3. Enzyme Inhibition and Induction - PK/PD Impact
- U. Klotz / K.T. Kivistö
- Download
- 11. Ethnic differences in drug response: A model for understanding interindividual variability
- A.J.J. Wood
- Download
- 19. Role of phenotyping and genotyping in the measurement of variability in human drug response
- J. Benítez
- Download
- 4. Adverse drug reactions: role of enzyme inhibition and induction
- M. Pirmohamed / B. Kevin Park
- Download
- 12. Effect of disease on the pharmacokinetic and pharmacodynamic determinants of response to diuretics
- D. Craig Brater
- Download
- 20. Population Modelling
- L. Aarons
- Download
- 5. Approaches to studying the role of transporters in drug interactions in man
- P.B. Watkins
- Download
- 13. Effects of exercise on human drug response
- M.A. van Baak
- Download
- 21. Can we design drugs with low variability
- D. Smith
- Download
- 6. Genetic polymorphisms in cardiovascular disease: focus on renin angiotensin system
- G.K. Davis / N.H. Naqvi
- Download
- 14. Benefit risk evaluation of medicinal products - an epidemiological approach
- C. Martinez
- Download
- 22. Management of variability through dosage form design
- P. du Souich / A.O.S. El-Kadi / A.M. Bleau
- Download
- Variability in human drug response Introduction
- G. Tucker
- Download
- 7. Pharmacogenetics of respiratory system drugs
- I.P. Hall
- Download
- 15. Pain - How to standardize a subjective measure
- E. Anneli Kalso
- Download
- 23. Management of Variability - Regulatory Aspects
- T. Salmonson / J.R. Wade
- Download
- Variability in human drug response List of participants
- Download
- 8. Tolerance as a Modulator of Drug Response
- N.L. Benowitz
- Download
- 16. Variable patient compliance as a source of variability in drug response
- J. Urquhart
- Download
- 1. Pharmacokinetic / pharmacodynamic impact of genetic polymorphism of drug metabolizing enzymes
- H.K. Kroemer / W. Siegmund
- Download
- 9. Variability in human drug response. Age as a source of variability
- M.T. Kinirons
- Download
- 17. Placebo Response
- M. Lader
- Download
