From clinical research to clinical pharmacology

Autor

F. Bosch / S. Erill

Año de publicación

2006

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Els articles que van jugar un paper rellevant en el desenvolupament de la Farmacologia Clínica és l’última proposta de la sèrie Pharmacotherapy Revisited. Aquesta col•lecció de la Fundació Dr. Antoni Esteve recopila en edició facsímil, tal com es va publicar en el seu moment, la literatura que al llarg dels anys va generar una determinada disciplina científica.

Els investigadors clínics, i en especial aquells que estan involucrats en assaigs clínics, estan irremeiablement familiaritzats amb conceptes com doble cec, randomització, anàlisi estadística o placebo, que ja formen part del seu dia a dia. En canvi, amb tota probabilitat, no tots han tingut la oportunitat d’assistir, des de la pròpia bibliografia, al naixement d’alguns d’aquests termes o, almenys, a l’ús precís que en feien les personalitats que han donat forma al camp de la Farmacologia Clínica.

Aquest volum número 7 de Pharmacotherapy Revisited fa la vista enrere i reuneix alguns dels articles científics que van crear un precedent en la historia de la Farmacologia Clínica. Des de l’ús de l’estetoscopi per a mesurar el ritme cardíac a l’encunyació del terme Farmacologia Clínica per part de Harry Gold el 1952. Els 30 articles següents, publicats en diferents revistes científiques entre 1931 i 1982 i reunits en aquest llibre, han estat seleccionats pels farmacòlegs Fèlix Bosch i Sergi Erill, de la Fundació Dr. Antoni Esteve:

Documento entero
Documento entero	F. Bosch / S. Erill	[wpdm type=”btn3″]
Capítulos
Acknowledgements		[wpdm id=31 type=”btn”]
Introduction	F. Bosch / S. Erill	[wpdm id=32 type=”btn”]
Index		[wpdm id=31 type=”btn”]
1. A clinical trial of sanocrysin in pulmonary tuberculosis	JB Amberson Jr / BT McMahon / M Pinner	[wpdm type=”btn3″]
2. The comparative value of drugs used in the continuous treatment of angina pectoris	W Evans / C Hoyle	[wpdm type=”btn3″]
3. The xanthines (theobromine and aminophylline) in the treatment of cardiac pain	H Gold / NT Kwit / H Otto	[wpdm type=”btn3″]
4. A method for the bio-assay of digitalis in humans	H Gold / M Cattell / HL Otto / NT Kwit / ML Kramer	[wpdm type=”btn3″]
5. Clinical trial of patulin in the common cold	MCR Patulin Clinical Trials Committee	[wpdm type=”btn3″]
6. Streptomycin treatment of pulmonary tuberculosis	MRC Streptomycin in Tuberculosis Trials Committee	[wpdm type=”btn3″]
7. A method for the evaluation of the effects of drugs on cardiac pain in patients with angina of effort: a study of khellin (visammin)	T Greiner / H Gold / M Cattell et al.	[wpdm type=”btn3″]
8. Measurement of pathological pain in distinction to experimental pain	AS Keats / HK Beecher / FC Mosteller	[wpdm type=”btn3″]
9. The role of dual reading in mass radiography	J Yerushalmy / JT Harkness / JH Cope / BR Kennedy	[wpdm type=”btn3″]
10. The clinical trial	AB Hill	[wpdm type=”btn3″]
11. Experimental pharmacology and measurement of the subjective response	HK Beecher	[wpdm type=”btn3″]
12. “The proper study of mankind is the man.”	H Gold	[wpdm type=”btn3″]
13. The physiological disposition of phenylbutazone (Butazolidin) in man and a method for its estimation in biological material	JJ Burns / RK Rose / T Chenkin / A Goldman / A Schulert / BB Brodie	[wpdm type=”btn3″]
14. Lind, lemons and limeys	SO Waife	[wpdm type=”btn3″]
15. How to evaluate a new drug	Conference on Therapy	[wpdm type=”btn3″]
16. Clinical pharmacology	JH Gaddum	[wpdm type=”btn3″]
17. The optimal dose of morphine	L Lasagna / HK Beecher	[wpdm type=”btn3″]
18. The powerful placebo	HK Beecher	[wpdm type=”btn3″]
19. Measurement in medicine	M Hamilton	[wpdm type=”btn3″]
20. Factors influencing clinical evaluation of drugs with special reference to the double-blind technique	W Modell / RW Houde	[wpdm type=”btn3″]
21. Amphetamine sulfate and athletic performance. I. Objective effects	GM Smith / HK Beecher	[wpdm type=”btn3″]
22. Transposition of drug studies from laboratory to clinic	KH Beyer	[wpdm type=”btn3″]
23. Some fallacies and errors in the application of the principle of consent in human experimentation	HK Beecher	[wpdm type=”btn3″]
24. Part VI. Difficulties in extrapolating data on metabolism of drugs from animals to man	BB Brodie	[wpdm type=”btn3″]
25. Patient selection and stratification in therapeutic trials	DR Laurence	[wpdm type=”btn3″]
26. Part IV. Placebos: Problems and pitfalls	S Wolf	[wpdm type=”btn3″]
27. Heberden Oration, 1965: Reflections on the controlled trial	AB Hill	[wpdm type=”btn3″]
28. Practical considerations in the design of clinical trials	EA Carr Jr	[wpdm type=”btn3″]
29. Clever Hans: The horse of Mr. Von Osten	W Modell	[wpdm type=”btn3″]
30. The role of randomization in clinical trials	P Armitage	[wpdm type=”btn3″]

From clinical research to clinical pharmacology Introduction
F. Bosch / S. Erill
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